METHADONE JUNKIE OPTIONS

[sixty one] Like several other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with distinct potency. Dextromethadone, that is a lot less potent being an opioid, is a lot more potent at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, with a